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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Uracil nucleotide/cysteinyl leukotriene receptor
Species	Homo sapiens (Human)
Gene	GPR17
Synonym	GPR17 P2Y-like receptor G-protein coupled receptor 17 R12 UDP/CysLT receptor uracil nucleotide/cysteinyl leukotriene receptor [ Show all ]
Disease	N/A
Length	367
Amino acid sequence	MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
UniProt	Q13304
Protein Data Bank	N/A
GPCR-HGmod model	Q13304
3D structure model	This predicted structure model is from GPCR-EXP Q13304.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075162
IUPHAR	88
DrugBank	N/A

Ligand

Name	CHEMBL53914
Molecular formula	C12H9F2NO4
IUPAC name	3-(2-carboxyethyl)-4,6-difluoro-1H-indole-2-carboxylic acid
Molecular weight	269.204
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	1.9
Synonyms	SCHEMBL14738976 2-Carboxy-4,6-difluoro-1H-indole-3-propionic acid
Inchi Key	JJZHXQCENKNTDW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H9F2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
PubChem CID	15747650
ChEMBL	CHEMBL53914
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	77.0 %	None	ChEMBL
Activity	97.0 %	None	ChEMBL
EC50	162.18 nM	None	ChEMBL
EC50	7413.1 nM	None	ChEMBL

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