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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 8
Species	Homo sapiens (Human)
Gene	CCR8
Synonym	GPRCY6 GPR-CY6 CMKBRL2 CKR-L1 ChemR1 Chemokine receptor-like 1 CCR8 CCR-8 CC-CKR-8 CC chemokine receptor CHEMR1 C-C CKR-8 TER1 [ Show all ]
Disease	Psoriasis
Length	355
Amino acid sequence	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProt	P51685
Protein Data Bank	N/A
GPCR-HGmod model	P51685
3D structure model	This predicted structure model is from GPCR-EXP P51685.
BioLiP	N/A
Therapeutic Target Database	T20575
ChEMBL	CHEMBL4596
IUPHAR	65
DrugBank	N/A

Ligand

Name	CHEMBL245365
Molecular formula	C24H23Cl2N3O5S
IUPAC name	3-[1-(3,4-dichlorophenyl)sulfonylpiperidin-4-yl]-5-(6-methoxyquinolin-4-yl)-1,3-oxazolidin-2-one
Molecular weight	536.424
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.3
Synonyms	N/A
Inchi Key	CYWUOUYBLQTFGG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H23Cl2N3O5S/c1-33-16-2-5-22-19(12-16)18(6-9-27-22)23-14-29(24(30)34-23)15-7-10-28(11-8-15)35(31,32)17-3-4-20(25)21(26)13-17/h2-6,9,12-13,15,23H,7-8,10-11,14H2,1H3
PubChem CID	44439911
ChEMBL	CHEMBL245365
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>50118.7 nM	PMID17267215	ChEMBL

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