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GPCR

NameChemokine-like receptor 1
SpeciesHomo sapiens (Human)
GeneCMKLR1
Synonymtazarotene induced gene 2 receptor
RVER1
resolvin E1 receptor
Gpcr27
G-protein coupled receptor DEZ
[ Show all ]
DiseaseN/A
Length373
Amino acid sequenceMRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
UniProtQ99788
Protein Data BankN/A
GPCR-HGmod modelQ99788
3D structure modelThis predicted structure model is from GPCR-EXP Q99788.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3540
IUPHAR79
DrugBankN/A

Ligand

NameCHEMBL3931112
Molecular formulaC27H27F6N3O2
IUPAC nameN-[3,5-bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-oxopyrrolidine-3-carboxamide
Molecular weight539.522
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP4.4
SynonymsSCHEMBL12728442
Inchi KeyLAPLFPPCLKKCFU-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H27F6N3O2/c1-16-5-4-6-17(2)23(16)36-15-25(14-22(36)37,18-7-9-35(3)10-8-18)24(38)34-21-12-19(26(28,29)30)11-20(13-21)27(31,32)33/h4-7,11-13H,8-10,14-15H2,1-3H3,(H,34,38)
PubChem CID51033453
ChEMBLCHEMBL3931112
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50>30.0 nMNoneChEMBL

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