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Name | Free fatty acid receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL3893026 |
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Molecular formula | C18H23Cl2NO2 |
IUPAC name | 2-[3-(3,5-dichlorophenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid |
Molecular weight | 356.287 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | BDBM50208157 SCHEMBL16482949 |
Inchi Key | LTCCGKRFGBBEHR-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23) |
PubChem CID | 73777153 |
ChEMBL | CHEMBL3893026 |
IUPHAR | N/A |
BindingDB | 50208157 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 6300.0 nM | PMID28105274 | BindingDB,ChEMBL |
IC50 | 2.6 nM | PMID28105274 | BindingDB |
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