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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL175211
Molecular formula	C28H25N3O2
IUPAC name	2-phenyl-N-[4-(5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepine-4-carbonyl)phenyl]benzamide
Molecular weight	435.527
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50370398
Inchi Key	CZEMALQIHKWPAQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H25N3O2/c32-27(24-11-5-4-10-23(24)20-8-2-1-3-9-20)30-22-15-13-21(14-16-22)28(33)31-19-7-6-12-25-26(31)17-18-29-25/h1-5,8-11,13-18,29H,6-7,12,19H2,(H,30,32)
PubChem CID	11270497
ChEMBL	CHEMBL175211
IUPHAR	N/A
BindingDB	50370398
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	200.0 nM	PMID7241506	BindingDB,ChEMBL

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