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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL3972601
Molecular formulaC12H11F3O5S2
IUPAC name2-[3-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-1,4-dithiepine 1,1,4,4-tetraoxide
Molecular weight356.33
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP1.9
Synonyms2-[3-(Trifluoromethoxy)phenyl]-6,7-dihydro-5H-1,4-dithiepin 1,1,4,4-tetraoxide
Inchi KeyOLXNBORTDITPJN-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H11F3O5S2/c13-12(14,15)20-10-4-1-3-9(7-10)11-8-21(16,17)5-2-6-22(11,18)19/h1,3-4,7-8H,2,5-6H2
PubChem CID9798779
ChEMBLCHEMBL3972601
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502700.0 nMNoneChEMBL

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