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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesMus musculus (Mouse)
GeneHtr1d
SynonymHTRL
Htr1db
HT1DA
Gpcr14
5-HT-1D
[ Show all ]
DiseaseN/A for non-human GPCRs
Length374
Amino acid sequenceMSPPNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKIS
UniProtQ61224
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4297
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3946540
Molecular formulaC21H25ClN2O2
IUPAC name(2S)-2-[(3-chlorophenoxy)methyl]-4-[2-(2,3-dihydroindol-1-yl)ethyl]morpholine
Molecular weight372.893
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.1
SynonymsSCHEMBL14060270
QAJBOIGVHPCSNX-FQEVSTJZSA-N
BDBM186935
US9079895, 23s
(S)-2-((3-chlorophenoxy)methyl)-4-(2-(indolin-1-yl)ethyl)morpholine
Inchi KeyQAJBOIGVHPCSNX-FQEVSTJZSA-N
Inchi IDInChI=1S/C21H25ClN2O2/c22-18-5-3-6-19(14-18)26-16-20-15-23(12-13-25-20)10-11-24-9-8-17-4-1-2-7-21(17)24/h1-7,14,20H,8-13,15-16H2/t20-/m0/s1
PubChem CID71061709
ChEMBLCHEMBL3946540
IUPHARN/A
BindingDB186935
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1121.0 nM, NoneBindingDB,ChEMBL

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