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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Mus musculus (Mouse)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C Serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	459
Amino acid sequence	MVNLGTAVRSLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVVRKANDTEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P34968
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3006
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3942898
Molecular formula	C21H25FN2O2
IUPAC name	(2S)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(4-fluorophenoxy)methyl]morpholine
Molecular weight	356.441
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.6
Synonyms	US9079895, 32s BDBM186969 SCHEMBL14150120
Inchi Key	RTXIZQIIOLWLRO-FQEVSTJZSA-N
Inchi ID	InChI=1S/C21H25FN2O2/c22-18-5-7-19(8-6-18)26-16-20-15-23(13-14-25-20)11-12-24-10-9-17-3-1-2-4-21(17)24/h1-8,20H,9-16H2/t20-/m0/s1
PubChem CID	71061611
ChEMBL	CHEMBL3942898
IUPHAR	N/A
BindingDB	186969
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1108.0 nM	, None	BindingDB,ChEMBL

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