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GPCR

NameC-C chemokine receptor-like 2
SpeciesHomo sapiens (Human)
GeneCCRL2
SynonymACR5
CRAM-B
CRAM-A
CKRX
Chemokine receptor X
[ Show all ]
DiseaseN/A
Length344
Amino acid sequenceMANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProtO00421
Protein Data BankN/A
GPCR-HGmod modelO00421
3D structure modelThis predicted structure model is from GPCR-EXP O00421.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2321627
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL9999217
Molecular formulaC24H29F5N6O
IUPAC nameN-[1-[4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Molecular weight512.529
Hydrogen bond acceptor11
Hydrogen bond donor2
XlogP4.1
SynonymsCHEMBL3926204
SCHEMBL9999219
BDBM163504
SCHEMBL15214528
US9062048, 131
Inchi KeyRVODGPORSRYQGF-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H29F5N6O/c25-23(26)7-8-34(13-23)17-2-4-18(5-3-17)35-11-16(12-35)33-21(36)10-30-22-19-9-15(24(27,28)29)1-6-20(19)31-14-32-22/h1,6,9,14,16-18H,2-5,7-8,10-13H2,(H,33,36)(H,30,31,32)
PubChem CID68004065
ChEMBLCHEMBL3926204
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50300.0 nMNoneChEMBL

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