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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3955499
Molecular formulaC21H25Cl2N5O3S
IUPAC name4-amino-3,5-dichloro-N-[4-(2-cyanopyrrol-1-yl)-1-(3-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
Molecular weight498.423
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.1
SynonymsBDBM50199084
SCHEMBL1076908
Inchi KeySTJFVBFBEPDAGK-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H25Cl2N5O3S/c1-14-4-2-8-28(13-14)21(29)19(6-9-27-7-3-5-15(27)12-24)26-32(30,31)16-10-17(22)20(25)18(23)11-16/h3,5,7,10-11,14,19,26H,2,4,6,8-9,13,25H2,1H3
PubChem CID58509063
ChEMBLCHEMBL3955499
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50630.96 nMPMID27692854ChEMBL

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