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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Free fatty acid receptor 4
Species	Mus musculus (Mouse)
Gene	Ffar4
Synonym	Omega-3 fatty acid receptor 1 O3FAR1 GT01 GPR129 GPR120 G-protein-coupled receptor GT01 G-protein coupled receptor GT01 G-protein coupled receptor 120 G protein-coupled receptor 129 G protein-coupled receptor 120 FFA4 receptor PGR4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	361
Amino acid sequence	MSPECAQTTGPGPSHTLDQVNRTHFPFFSDVKGDHRLVLSVVETTVLGLIFVVSLLGNVCALVLVARRRRRGATASLVLNLFCADLLFTSAIPLVLVVRWTEAWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLAFIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLVPGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIMWSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRNEWRKIFCCFFFPEKGAIFTDTSVRRNDLSVISS
UniProt	Q7TMA4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2052036
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1599477-75-4
Molecular formula	C19H23ClF3NO3
IUPAC name	2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Molecular weight	405.842
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	6.2
Synonyms	2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid CHEMBL3919973 HY-101492 D01VIX WUJVPELCYCESAP-UHFFFAOYSA-N 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5,5]undecan-9-yl)acetic acid BDBM50208095 GPR120-IN-1 3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid compound A [PMID 24997608] MolPort-039-136-860 AKOS025289518 EX-A1318 ZINC209053267 2-(3-(2-Chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)acetic acid GTPL8418 CS-6429 SCHEMBL16464406 BCP19379 GPR120 Compound A [ Show all ]
Inchi Key	WUJVPELCYCESAP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
PubChem CID	73777063
ChEMBL	CHEMBL3919973
IUPHAR	8418
BindingDB	50208095
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	33.0 nM	PMID28105274	BindingDB,ChEMBL
EC50	54.0 nM	PMID28105274	BindingDB,ChEMBL

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