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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3971461
Molecular formulaC18H13FN2O3S
IUPAC name2-(3-fluoro-5-pyridin-4-yloxyphenyl)-3H-1,2-benzothiazole 1,1-dioxide
Molecular weight356.371
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM50196401
Inchi KeyAEFPXUHUHYDYKB-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H13FN2O3S/c19-14-9-15(11-17(10-14)24-16-5-7-20-8-6-16)21-12-13-3-1-2-4-18(13)25(21,22)23/h1-11H,12H2
PubChem CID134153222
ChEMBLCHEMBL3971461
IUPHARN/A
BindingDB50196401
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<100000.0 nMPMID27570890ChEMBL
IC50>100000.0 nMPMID27570890BindingDB

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