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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL3981960
Molecular formulaC32H40F2N4O4
IUPAC name(16Z)-6-butan-2-yl-12-[(3,4-difluorophenyl)methyl]spiro[2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-9,1'-cyclopentane]-7,10,13-trione
Molecular weight582.693
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogP4.8
SynonymsN/A
Inchi KeyAGBRJUKCZYBIJH-NTMALXAHSA-N
Inchi IDInChI=1S/C32H40F2N4O4/c1-3-21(2)28-30(40)38-32(14-6-7-15-32)31(41)37-26(20-22-12-13-24(33)25(34)19-22)29(39)36-16-8-10-23-9-4-5-11-27(23)42-18-17-35-28/h4-5,8-13,19,21,26,28,35H,3,6-7,14-18,20H2,1-2H3,(H,36,39)(H,37,41)(H,38,40)/b10-8-
PubChem CID134157625
ChEMBLCHEMBL3981960
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki100.0 nMNoneChEMBL

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