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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001177315
Molecular formula	C25H26N2O4
IUPAC name	N-[2-[(2,3-dimethoxyphenyl)methyl-methylamino]-2-oxoethyl]-4-phenylbenzamide
Molecular weight	418.493
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	N-[2-[(2,3-dimethoxyphenyl)methyl-methyl-amino]-2-oxidanylidene-ethyl]-4-phenyl-benzamide 878212-71-6 HMS2899H04 Z31870592 AKOS034173564 MolPort-004-153-571 CHEMBL1478397 N-[2-[(2,3-dimethoxyphenyl)methyl-methylamino]-2-oxoethyl]-4-phenylbenzamide MCULE-3525273564 ZINC8036809 BDBM97141 N-[2-keto-2-[methyl(o-veratryl)amino]ethyl]-4-phenyl-benzamide 2-({[1,1'-biphenyl]-4-yl}formamido)-N-[(2,3-dimethoxyphenyl)methyl]-N-methylacetamide cid_9166749 SMR000595026 AC1PMG7S [ Show all ]
Inchi Key	CZYJLQYRCXIZPK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H26N2O4/c1-27(17-21-10-7-11-22(30-2)24(21)31-3)23(28)16-26-25(29)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15H,16-17H2,1-3H3,(H,26,29)
PubChem CID	9166749
ChEMBL	CHEMBL1478397
IUPHAR	N/A
BindingDB	97141
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1108.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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