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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3921062
Molecular formulaC19H14F4O4
IUPAC name3-[5-[2-fluoro-5-(trifluoromethoxy)phenyl]-1-benzofuran-2-yl]-2-methylpropanoic acid
Molecular weight382.311
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.6
SynonymsBDBM50203662
Inchi KeyAGPNPJDYUDCBPM-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H14F4O4/c1-10(18(24)25)6-14-8-12-7-11(2-5-17(12)26-14)15-9-13(3-4-16(15)20)27-19(21,22)23/h2-5,7-10H,6H2,1H3,(H,24,25)
PubChem CID134140073
ChEMBLCHEMBL3921062
IUPHARN/A
BindingDB50203662
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<9950.0 nMPMID27815121BindingDB,ChEMBL

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