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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 88
Species	Homo sapiens (Human)
Gene	GPR88
Synonym	GPR88 STRG striatum-specific G-protein coupled receptor
Disease	N/A
Length	384
Amino acid sequence	MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProt	Q9GZN0
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZN0
3D structure model	This predicted structure model is from GPCR-EXP Q9GZN0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3399910
IUPHAR	123
DrugBank	N/A

Ligand

Name	CHEMBL3884736
Molecular formula	C23H28FNO4
IUPAC name	methyl (2R)-2-[[2-(4-fluorophenyl)acetyl]amino]-2-[4-(2-methylpentoxy)phenyl]acetate
Molecular weight	401.478
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.1
Synonyms	BDBM50209614
Inchi Key	AYRYEYLUDKEVTH-VXNXSFHZSA-N
Inchi ID	InChI=1S/C23H28FNO4/c1-4-5-16(2)15-29-20-12-8-18(9-13-20)22(23(27)28-3)25-21(26)14-17-6-10-19(24)11-7-17/h6-13,16,22H,4-5,14-15H2,1-3H3,(H,25,26)/t16?,22-/m1/s1
PubChem CID	134130956
ChEMBL	CHEMBL3884736
IUPHAR	N/A
BindingDB	50209614
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5860.0 nM	PMID27956039	BindingDB,ChEMBL
EC50	5888.0 nM	PMID27956039	BindingDB
EC50	5888.44 nM	PMID27956039	ChEMBL

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