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GPCR

NameProteinase-activated receptor 2
SpeciesHomo sapiens (Human)
GeneF2RL1
SynonymProtease-activated receptor-2
PAR2
PAR-2
GPR11
G-protein coupled receptor 11
[ Show all ]
DiseaseN/A
Length397
Amino acid sequenceMRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProtP55085
Protein Data Bank5ndz, 5ndd
GPCR-HGmod modelP55085
3D structure modelThis structure is from PDB ID 5ndz.
BioLiPBL0377325, BL0377326
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5963
IUPHAR348
DrugBankN/A

Ligand

NameCHEMBL3895574
Molecular formulaC30H42FN5O4
IUPAC nameN-[(2S)-3-cyclohexyl-1-[[(2S,3S)-1-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-1,2-oxazole-5-carboxamide
Molecular weight555.695
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP5.1
SynonymsN/A
Inchi KeyAZJKAQFVAXYXJK-NOOLENRPSA-N
Inchi IDInChI=1S/C30H42FN5O4/c1-3-21(2)27(30(39)36-17-15-35(16-18-36)20-23-9-11-24(31)12-10-23)34-28(37)25(19-22-7-5-4-6-8-22)33-29(38)26-13-14-32-40-26/h9-14,21-22,25,27H,3-8,15-20H2,1-2H3,(H,33,38)(H,34,37)/t21-,25-,27-/m0/s1
PubChem CID134136425
ChEMBLCHEMBL3895574
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity30.0 %PMID27994760ChEMBL

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