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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesHomo sapiens (Human)
GeneGPR119
SynonymGPCR2
GPR119
G-protein coupled receptor 2
G-protein coupled receptor 119
G protein-coupled receptor 119
[ Show all ]
DiseaseType 2 diabetes
Diabetes
Peripheral arterial disease; Type 2 diabetes
Non-insulin dependent diabetes
Gastric cancer; Type 2 diabetes
Length335
Amino acid sequenceMESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProtQ8TDV5
Protein Data BankN/A
GPCR-HGmod modelQ8TDV5
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDV5.
BioLiPN/A
Therapeutic Target DatabaseT93788
ChEMBLCHEMBL5652
IUPHAR126
DrugBankN/A

Ligand

NameCHEMBL3986478
Molecular formulaC23H27N7O4
IUPAC nametert-butyl (1R,5R)-3-[[6-(2-cyanoanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Molecular weight465.514
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP5.1
SynonymsBDBM50204221
Inchi KeyBGFIONADBDERJX-IAGOWNOFSA-N
Inchi IDInChI=1S/C23H27N7O4/c1-23(2,3)34-22(31)29-16-8-9-17(29)11-15(10-16)27-20-19(30(32)33)21(26-13-25-20)28-18-7-5-4-6-14(18)12-24/h4-7,13,15-17H,8-11H2,1-3H3,(H2,25,26,27,28)/t16-,17-/m1/s1
PubChem CID134156472
ChEMBLCHEMBL3986478
IUPHARN/A
BindingDB50204221
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<2000.0 nMPMID27825553BindingDB,ChEMBL
Emax46.2 %PMID27825553ChEMBL

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