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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3898424
Molecular formulaC19H16ClF3N6O2
IUPAC nameN-[3-chloro-4-[(2R)-morpholin-2-yl]phenyl]-1-[6-(trifluoromethyl)pyrazin-2-yl]pyrazole-4-carboxamide
Molecular weight452.822
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP1.5
SynonymsN/A
Inchi KeyCTQVVHSCIIODID-HNNXBMFYSA-N
Inchi IDInChI=1S/C19H16ClF3N6O2/c20-14-5-12(1-2-13(14)15-7-24-3-4-31-15)27-18(30)11-6-26-29(10-11)17-9-25-8-16(28-17)19(21,22)23/h1-2,5-6,8-10,15,24H,3-4,7H2,(H,27,30)/t15-/m0/s1
PubChem CID134133251
ChEMBLCHEMBL3898424
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki8.8 nMNoneChEMBL

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