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Name | Gastrin-releasing peptide receptor |
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Species | Homo sapiens (Human) |
Gene | GRPR |
Synonym | GRP-R GRP-preferring bombesin receptor gastrin-releasing peptide receptor BB2 receptor BB2 |
Disease | Solid tumours Breast cancer Cancer Irritable bowel syndrome |
Length | 384 |
Amino acid sequence | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV |
UniProt | P30550 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30550 |
3D structure model | This predicted structure model is from GPCR-EXP P30550. |
BioLiP | N/A |
Therapeutic Target Database | T99816 |
ChEMBL | CHEMBL4959 |
IUPHAR | 39 |
DrugBank | N/A |
Name | CHEMBL3908400 |
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Molecular formula | C70H112N24O17S2 |
IUPAC name | (2S)-2-[[(2S)-1-[[2-[4-[2-[[(2R)-3-(acetamidomethylsulfanyl)-2-[[(2S)-2-[[2-(dimethylamino)acetyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]acetyl]piperazin-1-yl]acetyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide |
Molecular weight | 1625.94 |
Hydrogen bond acceptor | 24 |
Hydrogen bond donor | 20 |
XlogP | -4.6 |
Synonyms | N/A |
Inchi Key | GMXZCVRRZVYOJD-USAPKUQSSA-N |
Inchi ID | InChI=1S/C70H112N24O17S2/c1-38(2)25-49(66(108)86-46(60(72)102)18-24-112-9)87-67(109)51(27-43-29-75-36-80-43)84-55(98)30-78-69(111)59(39(3)4)91-61(103)40(5)82-65(107)50(26-42-28-77-45-14-11-10-13-44(42)45)88-63(105)48(16-17-54(71)97)83-47(15-12-19-76-70(73)74)64(106)90-57(100)33-93-20-22-94(23-21-93)58(101)31-79-62(104)53(35-113-37-81-41(6)96)89-68(110)52(34-95)85-56(99)32-92(7)8/h10-11,13-14,28-29,36,38-40,46-53,59,77,83,95H,12,15-27,30-35,37H2,1-9H3,(H2,71,97)(H2,72,102)(H,75,80)(H,78,111)(H,79,104)(H,81,96)(H,82,107)(H,84,98)(H,85,99)(H,86,108)(H,87,109)(H,88,105)(H,89,110)(H,91,103)(H4,73,74,76)(H,90,100,106)/t40-,46-,47-,48-,49-,50-,51-,52-,53-,59-/m0/s1 |
PubChem CID | 134132419 |
ChEMBL | CHEMBL3908400 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 26.0 nM | None | ChEMBL |
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