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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3900705
Molecular formulaC21H22FNO4
IUPAC name3-[(2R)-6-(5-cyclobutyloxy-2-fluoropyridin-3-yl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Molecular weight371.408
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.1
SynonymsBDBM50207068
Inchi KeyHGDFRNBNPYHIOH-MRXNPFEDSA-N
Inchi IDInChI=1S/C21H22FNO4/c22-21-18(11-17(12-23-21)26-15-2-1-3-15)13-5-8-19-14(10-13)4-6-16(27-19)7-9-20(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
PubChem CID134133992
ChEMBLCHEMBL3900705
IUPHARN/A
BindingDB50207068
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity<50.0 %PMID28105282ChEMBL
EC5079.0 nMPMID28105282BindingDB,ChEMBL
EC50140.0 nMPMID28105282BindingDB,ChEMBL

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