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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 88
Species	Homo sapiens (Human)
Gene	GPR88
Synonym	GPR88 STRG striatum-specific G-protein coupled receptor
Disease	N/A
Length	384
Amino acid sequence	MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProt	Q9GZN0
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZN0
3D structure model	This predicted structure model is from GPCR-EXP Q9GZN0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3399910
IUPHAR	123
DrugBank	N/A

Ligand

Name	CHEMBL3885410
Molecular formula	C25H34N2O3
IUPAC name	(2S)-N-[(1R)-2-(dimethylamino)-1-[4-(2-methylpentoxy)phenyl]-2-oxoethyl]-2-phenylpropanamide
Molecular weight	410.558
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.1
Synonyms	BDBM50209624
Inchi Key	MUTBEIGKAHNCFX-HXCXSPQYSA-N
Inchi ID	InChI=1S/C25H34N2O3/c1-6-10-18(2)17-30-22-15-13-21(14-16-22)23(25(29)27(4)5)26-24(28)19(3)20-11-8-7-9-12-20/h7-9,11-16,18-19,23H,6,10,17H2,1-5H3,(H,26,28)/t18?,19-,23+/m0/s1
PubChem CID	134130466
ChEMBL	CHEMBL3885410
IUPHAR	N/A
BindingDB	50209624
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	616.0 nM	PMID27956039	BindingDB,ChEMBL
EC50	616.6 nM	PMID27956039	ChEMBL
EC50	617.0 nM	PMID27956039	BindingDB

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