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GPCR

NameProbable G-protein coupled receptor 142
SpeciesMus musculus (Mouse)
GeneGpr142
SynonymG-protein coupled receptor PGR2
GPR142
KIF19
AXOR103
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
UniProtQ7TQN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069162
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3903475
Molecular formulaC20H15Cl2FN6O
IUPAC nameN-(2,3-dichlorophenyl)-2-[4-[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide
Molecular weight445.279
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.9
SynonymsBDBM50201575
Inchi KeyPRSMZNFUKBHAIS-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)18-6-5-13(7-15(18)23)17-9-29(27-26-17)10-19(30)25-16-4-2-3-14(21)20(16)22/h2-9,11H,10H2,1H3,(H,25,30)
PubChem CID134135307
ChEMBLCHEMBL3903475
IUPHARN/A
BindingDB50201575
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC509.0 nMPMID27994747BindingDB
EC509.0 nMPMID27994747ChEMBL
EC5078.0 nMPMID27994747BindingDB,ChEMBL

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