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Name | Free fatty acid receptor 1 |
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Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL3906716 |
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Molecular formula | C19H23F4NO3 |
IUPAC name | 4-[1-[2-fluoro-5-(trifluoromethoxy)phenyl]piperidin-4-yl]cyclohexane-1-carboxylic acid |
Molecular weight | 389.391 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 5.4 |
Synonyms | BDBM50208156 |
Inchi Key | QGWKREOBRUYESR-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26) |
PubChem CID | 134135468 |
ChEMBL | CHEMBL3906716 |
IUPHAR | N/A |
BindingDB | 50208156 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <10000.0 nM | PMID28105274 | BindingDB,ChEMBL |
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