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GPCR

NameD(1A) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd1
SynonymD1 receptor
D1A
DADR
Dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtQ61616
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3071
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3963147
Molecular formulaC22H27N3O3
IUPAC name1-(2-methyl-2,3-dihydroindol-1-yl)-2-[(2S)-2-[(4-methylpyridin-2-yl)oxymethyl]morpholin-4-yl]ethanone
Molecular weight381.476
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.8
SynonymsN/A
Inchi KeyZGWKETCDELPQRC-NNBQYGFHSA-N
Inchi IDInChI=1S/C22H27N3O3/c1-16-7-8-23-21(11-16)28-15-19-13-24(9-10-27-19)14-22(26)25-17(2)12-18-5-3-4-6-20(18)25/h3-8,11,17,19H,9-10,12-15H2,1-2H3/t17?,19-/m0/s1
PubChem CID134152286
ChEMBLCHEMBL3963147
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMNoneChEMBL

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