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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonym5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
'D' receptor
5-HT-2A
serotonin receptor 2A
5Ht-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

Nametryptamine
Molecular formulaC10H12N2
IUPAC name2-(1H-indol-3-yl)ethanamine
Molecular weight160.22
Hydrogen bond acceptor1
Hydrogen bond donor2
XlogP1.6
Synonyms(3-Indolyl)ethylamine
(Amino-2 ethyl)-3 indole
(Amino-2 ethyl)-3 indole [French]
.beta.-(3-Indolyl)ethylamine
005T661
[ Show all ]
Inchi KeyAPJYDQYYACXCRM-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
PubChem CID1150
ChEMBLCHEMBL6640
IUPHAR125
BindingDB50024210
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID8510008BindingDB
Ki11.0 nMPMID2795135BindingDB
Ki25.11 nMPMID7984267BindingDB
Ki79.4328 nMPMID8114677IUPHAR
Ki416.86 nMPMID9225287BindingDB
Ki538.0 nMPMID6645787BindingDB
Ki1682.0 nMPMID6645787BindingDB
Ki2932.0 nMPMID6645787BindingDB
Ki3890.45 nMPMID7984267BindingDB

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