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GPCR

NameLysophosphatidic acid receptor 3
SpeciesMus musculus (Mouse)
GeneLpar3
SynonymEdg7
endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7
LPA-3
Lysophosphatidic acid receptor Edg-7
LPA receptor 3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSETGSQYLEDSISQGPVCNKNGS
UniProtQ9EQ31
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR274
DrugBankN/A

Ligand

NameNAEPA
Molecular formulaC20H40NO5P
IUPAC name2-[[(E)-octadec-9-enoyl]amino]ethyl dihydrogen phosphate
Molecular weight405.516
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP5.2
SynonymsN-acyl ethanolamide phosphate
24435-25-4
(Z)-N-[2-(Phosphonooxy)ethyl]-9-octadecenamide
D0R8LB
GTPL6982
[ Show all ]
Inchi KeyBCSUWOZFWWBYSX-MDZDMXLPSA-N
Inchi IDInChI=1S/C20H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)21-18-19-26-27(23,24)25/h9-10H,2-8,11-19H2,1H3,(H,21,22)(H2,23,24,25)/b10-9+
PubChem CID17757220
ChEMBLN/A
IUPHAR6982
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<5000.0 nMPMID18781939IUPHAR

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