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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameMeTRH
Molecular formulaC17H24N6O4
IUPAC name(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-5-oxopyrrolidine-2-carboxamide
Molecular weight376.417
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP-2.3
SynonymsCTK1A8669
L-Prolinamide, 1-methyl-5-oxo-L-prolyl-L-histidyl-
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-5-oxopyrrolidine-2-carboxamide
DTXSID50415524
pGlu-His(1(tau)-methyl)-ProNH2
[ Show all ]
Inchi KeyDJLHRAHTTSWYAW-AVGNSLFASA-N
Inchi IDInChI=1S/C17H24N6O4/c1-22-13(4-5-14(22)24)16(26)21-11(7-10-8-19-9-20-10)17(27)23-6-2-3-12(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,19,20)(H,21,26)/t11-,12-,13-/m0/s1
PubChem CID5311291
ChEMBLN/A
IUPHAR2137, 2141
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.16228 nMPMID5001013IUPHAR

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