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GPCR

NameD(2) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP20288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3998
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL538235
Molecular formulaC15H22ClNO2
IUPAC name6-[2-chloroethyl(propyl)amino]-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight283.796
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.5
Synonyms6-[(2-Chloro-ethyl)-propyl-amino]-5,6,7,8-tetrahydro-naphthalene-2,3-diol; hydrobromide
BDBM50024703
CHEMBL1189177
Inchi KeyAHGZCCQSSLOYRT-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H22ClNO2/c1-2-6-17(7-5-16)13-4-3-11-9-14(18)15(19)10-12(11)8-13/h9-10,13,18-19H,2-8H2,1H3
PubChem CID13897490
ChEMBLN/A
IUPHARN/A
BindingDB50024703
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5076.0 nMPMID3656361BindingDB
IC50260.0 nMPMID3656361BindingDB

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