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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesMus musculus (Mouse)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceMDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT
UniProtP97288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2183
IUPHAR9
DrugBankN/A

Ligand

NameSDZ-205557
Molecular formulaC14H21ClN2O3
IUPAC name2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight300.783
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.2
SynonymsBiomol-NT_000157
CTK4C0686
LS-187597
PDSP2_001652
137196-67-9
[ Show all ]
Inchi KeyFFNWMBDISAYHDC-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
PubChem CID5191
ChEMBLCHEMBL287045
IUPHAR258
BindingDB50056401
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki6.3 nMPMID8867105, PMID8946946BindingDB
Ki7.76 nMPMID8946946BindingDB
Ki7.94328 nMPMID7498967IUPHAR

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