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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 4
Species	Homo sapiens (Human)
Gene	CCR4
Synonym	K5-5 ChemR13 chemokine (C-C motif) receptor 4 CD194 CCR4 CCR-4 CC-CKR-4 CC CKR4 C-C CKR-4 C-C chemokine receptor 4 [ Show all ]
Disease	Asthma Atopic dermatitis Autoimmune diabetes
Length	360
Amino acid sequence	MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
UniProt	P51679
Protein Data Bank	N/A
GPCR-HGmod model	P51679
3D structure model	This predicted structure model is from GPCR-EXP P51679.
BioLiP	N/A
Therapeutic Target Database	T06955
ChEMBL	CHEMBL2414
IUPHAR	61
DrugBank	N/A

Ligand

Name	AZD2098
Molecular formula	C11H9Cl2N3O3S
IUPAC name	2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
Molecular weight	334.171
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.6
Synonyms	AZD-2098 SCHEMBL1731222 2,3-dichloro-N-(3-methoxypyrazin-2-yl)-benzenesulfonamide compound 47 [PMID: 28947948] GTPL9678 ZINC38476960 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide CS-6789 AZD 2098 HY-U00064 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulphonamide BCP28962 566203-88-1 FLSMVCMSUNISFK-UHFFFAOYSA-N [ Show all ]
Inchi Key	FLSMVCMSUNISFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16)
PubChem CID	10308720
ChEMBL	N/A
IUPHAR	9678
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	15.8 nM	PMID28947948	IUPHAR

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