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Name | Metabotropic glutamate receptor 3 |
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Species | Homo sapiens (Human) |
Gene | GRM3 |
Synonym | GPRC1C mGluR3 mGlu3 receptor glutamate receptor |
Disease | Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia |
Length | 879 |
Amino acid sequence | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | Q14832 |
Protein Data Bank | 3sm9, 6b7h, 4xar, 5cnk, 5cnm |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 3sm9. |
BioLiP | BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561 |
Therapeutic Target Database | T02719 |
ChEMBL | CHEMBL2888 |
IUPHAR | 291 |
DrugBank | N/A |
Name | D0N9UZ |
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Molecular formula | C12H13N5O6 |
IUPAC name | (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(2,6-dioxo-3H-purin-9-yl)ethyl]cyclopropane-1-carboxylic acid |
Molecular weight | 323.265 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 5 |
XlogP | -4.7 |
Synonyms | CTK8F0257 (1S,2S)-2-[(2S)-2-amino-3-(2,6-dioxo-3H-purin-9-yl)-1-hydroxy-1-oxopropan-2-yl]cyclopropane-1-carboxylic acid AC1O44IH AN-16504 (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(2,6-dioxo-3H-purin-9-yl)ethyl]cyclopropanecarboxylic acid [ Show all ] |
Inchi Key | GTVQXKHWYDSDNM-JRHNIRLTSA-N |
Inchi ID | InChI=1S/C12H13N5O6/c13-12(10(21)22,5-1-4(5)9(19)20)2-17-3-14-6-7(17)15-11(23)16-8(6)18/h3-5H,1-2,13H2,(H,19,20)(H,21,22)(H2,15,16,18,23)/t4-,5-,12+/m0/s1 |
PubChem CID | 6324636 |
ChEMBL | N/A |
IUPHAR | 1399, 1378 |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 0.794328 nM | PMID10530814 | IUPHAR |
Ki | 1.25893 nM | PMID10530814 | IUPHAR |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218