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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 4
Species	Rattus norvegicus (Rat)
Gene	P2ry4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 NRU uridine nucleotide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	361
Amino acid sequence	MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALVTLHEESISRWADTHQDSTFSAYEGDRL
UniProt	O35811
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2124
IUPHAR	325
DrugBank	N/A

Ligand

Name	inosine triphosphate
Molecular formula	C10H15N4O14P3
IUPAC name	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	508.165
Hydrogen bond acceptor	16
Hydrogen bond donor	7
XlogP	-5.1
Synonyms	bmse000255 Inosine 5 Inosine-5'-Triphosphate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate 5'-ITP CHEMBL1233686 Inosine 5'-triphosphate LS-84004 ({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid AC1Q6S2R EINECS 205-046-7 UNII-212A76R77X 2'-inosine-5'-triphosphate C00081 Inosine 5'-(tetrahydrogen triphosphate) ITP [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate 5-ITP D00WOK Inosine 5(tetrahydrogen triphosphate) O(5')-(tetrahydroxytriphosphoryl)inosine 132-06-9 AJ-57364 GTPL1743 Inosine tripolyphosphate ZINC8215530 212A76R77X CHEBI:16039 Inosine 5'-(tetrahydrogen triphosphate) (8CI,9CI) ITT AC1L1RAP DTXSID8074499 Inosine 5-triphopshate SCHEMBL163281 [ Show all ]
Inchi Key	HAEJPQIATWHALX-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	135398643
ChEMBL	N/A
IUPHAR	1743
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1584.89 - 1995.26 nM	PMID9647463, PMID10779375	IUPHAR

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