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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	AH 23848
Molecular formula	C29H35NO5
IUPAC name	(E)-7-[2-morpholin-4-yl-3-oxo-5-[(4-phenylphenyl)methoxy]cyclopentyl]hept-4-enoic acid
Molecular weight	477.601
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.6
Synonyms	7-(5-(((1,1-biphenyl)-4-yl)methoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-4-heptanoic acid GTPL1950 (E)-7-[2-morpholin-4-yl-3-oxo-5-[(4-phenylphenyl)methoxy]cyclopentyl]hept-4-enoic acid SCHEMBL10414714 4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-, (1alpha(Z),2beta,5alpha)-(+-)- AH23848 (racemic) 81443-73-4 L000100 AH 23848B 4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-,(1-alpha(Z),2-beta,5-alpha)-(+-)- BRN 4279184 (1-alpha(z),2-beta,5-alpha)-dl-7-(5-((1,1-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl) AC1O5JQF LS-74566 4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-, (1-alpha(Z),2-beta,5-alpha)-(+-)- AH-23848 [ Show all ]
Inchi Key	IOFUFYLETVNNRF-OWOJBTEDSA-N
Inchi ID	InChI=1S/C29H35NO5/c31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30/h1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33)/b2-1+
PubChem CID	6435402
ChEMBL	N/A
IUPHAR	1950
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	10000.0 nM	PMID9537820	IUPHAR

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