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GPCR

Name	P2Y purinoceptor 11
Species	Homo sapiens (Human)
Gene	P2RY11
Synonym	P2Y11 P2Y11 receptor purinergic receptor P2Y, G-protein coupled, 11
Disease	N/A
Length	374
Amino acid sequence	MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
UniProt	Q96G91
Protein Data Bank	N/A
GPCR-HGmod model	Q96G91
3D structure model	This predicted structure model is from GPCR-EXP Q96G91.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4867
IUPHAR	327
DrugBank	BE0005499

Ligand

Name	Affi gel blue
Molecular formula	C29H20ClN7O11S3
IUPAC name	1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid
Molecular weight	774.147
Hydrogen bond acceptor	18
Hydrogen bond donor	7
XlogP	4.4
Synonyms	1-Amino-4-((4-((4-chloro-6-((3(or4)-sulphophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulphophenyl)amino)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonic acid 1-amino-4-[[4-[[4-chloro-6-[(3-sulfophenyl)amino]-1,3,5-triazin-2-yl]amino]-3-sulfophenyl]amino]-9,10-dioxoanthracene-2-sulfonic acid 26763-68-8 BDBM50179359 Cibacron Blue F(3)GA J0A052J6QF T654 1-Amino-4-((4-((4-chloro-6-((sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo- 802902-10-9 C13746 D06GJP NSC 328383 ZINC8295160 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-(4-((4-chloro-6-(sulfoanilino)-s-triazin-2-yl)amino)-3-sulfoanilino)-9,10-dihydro-9,10-dioxo- (8CI) Affi-gel blue Cibacron Blue 3G FT-0699654 Reactive Blue-2 1-Amino-4-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 12237-92-2 778536-90-6 C.I. 61211 Cibacronblau F3G-A L000507 UNII-5DV0L8V99J component JQYMGXZJTCOARG-UHFFFAOYSA-N 1-amino-4-(4-(4-chloro-6-(3-sulfophenylamino)-1,3,5-triazin-2-ylamino)-3-sulfophenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo- AC1LCVHE CHEBI:34946 EINECS 235-465-0 Procion Blue H-B 1-AMINO-4-[[4-[[4-CHLORO-6-[(3-SULFOPHENYL)AMINO]-1,3,5-TRIAZIN-2-YL]A MINO]-3-SULFO-PHENYL]AMINO]-9,10-DIOXO-ANTHRACENE-2-SULFONIC ACID 2-Anthraquinonesulfonic acid, 1-amino-4-(4-((4-chloro-6-m-sulfoanilino-S-triazin-2-yl)amino)-3-sulfoanilino)- Basilen Blue Cibacron Blue F 3GA GTPL1739 SCHEMBL1638291 1-amino-4-((4-((4-chloro-6-((sulfophenyl)amino)- 1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)- 9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 79241-87-5 C.I. Reactive Blue 2 CTK4F8482 LS-172530 UNII-J0A052J6QF 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfo-anilino]-9,10-dioxo-anthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-(4-((4-chloro-6-(sulfoanilino)-s-triazin-2-yl)amino)-3-sulfoanilino)-9,10-dihydro-9,10-dioxo- CHEMBL1160031 FT-0699643 Reactive blue 2 (C.I. 61211) [ Show all ]
Inchi Key	JQYMGXZJTCOARG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)
PubChem CID	656725
ChEMBL	N/A
IUPHAR	1739
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10000.0 nM	PMID10578132	IUPHAR

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