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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 2
Species	Homo sapiens (Human)
Gene	PROKR2
Synonym	PKR2 PK-R2 I5E GPRg2 GPR73b GPR73a G-protein coupled receptor I5E G-protein coupled receptor 73-like 1 VEGFR-2 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
UniProt	Q8NFJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q8NFJ6
3D structure model	This predicted structure model is from GPCR-EXP Q8NFJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5548
IUPHAR	336
DrugBank	N/A

Ligand

Name	PKR-A
Molecular formula	C26H34N2O4
IUPAC name	4-benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-(2-methylpropyl)morpholine-2-carboxamide
Molecular weight	438.568
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.8
Synonyms	N-(3,4-dihydro-2H-1,5-benzodioxepin-8-ylmethyl)-N-(2-methylpropyl)-4-(phenylmethyl)morpholine-2-carboxamide (-)-4-Benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide GTPL6066 KQQGCZSZDMHKOX-UHFFFAOYSA-N (+/-)-4-Benzyl-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-N-isobutylmorpholine-2-carboxamide SCHEMBL387975 D03TIA [ Show all ]
Inchi Key	KQQGCZSZDMHKOX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H34N2O4/c1-20(2)16-28(18-22-9-10-23-24(15-22)31-13-6-12-30-23)26(29)25-19-27(11-14-32-25)17-21-7-4-3-5-8-21/h3-5,7-10,15,20,25H,6,11-14,16-19H2,1-2H3
PubChem CID	16122905
ChEMBL	N/A
IUPHAR	6066
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	43.5 - 52.7 nM	PMID22431614	IUPHAR

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