Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Adhesion G protein-coupled receptor G3
Species	Homo sapiens (Human)
Gene	ADGRG3
Synonym	ADGRG3 G-protein coupled receptor 97 G-protein coupled receptor PGR26 GPR97 (G protein-coupled receptor 97) Pb99
Disease	N/A
Length	549
Amino acid sequence	MATPRGLGALLLLLLLPTSGQEKPTEGPRNTCLGSNNMYDIFNLNDKALCFTKCRQSGSDSCNVENLQRYWLNYEAHLMKEGLTQKVNTPFLKALVQNLSTNTAEDFYFSLEPSQVPRQVMKDEDKPPDRVRLPKSLFRSLPGNRSVVRLAVTILDIGPGTLFKGPRLGLGDGSGVLNNRLVGLSVGQMHVTKLAEPLEIVFSHQRPPPNMTLTCVFWDVTKGTTGDWSSEGCSTEVRPEGTVCCCDHLTFFALLLRPTLDQSTVHILTRISQAGCGVSMIFLAFTIILYAFLRLSRERFKSEDAPKIHVALGGSLFLLNLAFLVNVGSGSKGSDAACWARGAVFHYFLLCAFTWMGLEAFHLYLLAVRVFNTYFGHYFLKLSLVGWGLPALMVIGTGSANSYGLYTIRDRENRTSLELCWFREGTTMYALYITVHGYFLITFLFGMVVLALVVWKIFTLSRATAVKERGKNRKKVLTLLGLSSLVGVTWGLAIFTPLGLSTVYIFALFNSLQGVFICCWFTILYLPSQSTTVSSSTARLDQAHSASQE
UniProt	Q86Y34
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	188
DrugBank	N/A

Ligand

Name	BECLOMETHASONE DIPROPIONATE
Molecular formula	C28H37ClO7
IUPAC name	[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
Molecular weight	521.047
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.0
Synonyms	DSSTox_RID_82926 5B307S63B2 HMS3259H03 AB1009261 LS-118439 Aldecina Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11.beta.,16.beta.)- Beclazone Prestwick_990 Beclometasone dipropionate Qvar 80 Beclomethasone dipropionate [USAN] SCH 18020W Beclovent (TN) UNII-5B307S63B2 [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate C07813 Clenil-A 32278-EP2295408A1 32278-EP2311827A1 Entyderma 9-Chloro-11beta, 17,21-trihydroxy-16 beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate Inalone O AC1Q62MZ MLS002154034 API0001601 Pregna-1-4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-,17,21-dipropionate Becloforte Propionic acid beclomethasone Beclometasone dipropionate for system suitability, European Pharmacopoeia (EP) Reference Standard Rhinosol Beclomethasone Dipropionate, Pharmaceutical Secondary Standard; Certified Reference Material SPBio_002790 Benconase Vanceril (TN) CCG-220855 CTK8F7938 DSSTox_CID_28656 5534-09-8 HMS2097L11 9-Chloro-11\|A,17,21-trihydroxy-16\|A-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate KUVIULQEHSCUHY-XYWKZLDCSA-N Alanase NCGC00094596-03 Beclacin Prestwick2_000855 Beclometasone (beclomethasone) dipropionate, British Pharmacopoeia (BP) Assay Standard Qvar Beclomethasone dipropionate (USP) Sanasthmax Becloturmant Tox21_113168 [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate BRD-K97810537-001-13-6 Viarox CHEMBL1200500 2-[(1R,2S,10S,11S,13S,14R,15S,17S)-1-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate DTXSID3048730 9-AE-11\|A,17,21-EyoC>>u-16\|A-(1/4)x>>uOEthcThorn-1,4- paragraph signthornI(c)-3,20- paragraph signthornI feminine-17,21- paragraph signthorn+/-uEao yen HMS3714L11 AC-2159 Menaderm Aldecine Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)- Beclazone 250 Propaderm Beclometasone dipropionate (JP17) Respocort Beclomethasone dipropionate, analytical standard, for drug analysis SCHEMBL6890 Beconase Vancenase C28H37ClO7 CPD001233361 32278-EP2301933A1 34135-07-4 GTPL5894 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate Inalone R Aerobec MolPort-003-983-412 Atomase Prestwick0_000855 Beclomet QNASL Beclometasone dipropionato Rino-clenil Beclomethasone dipropionate, United States Pharmacopeia (USP) Reference Standard Spir W-5080 BPBio1_000957 Vanceril Double Strength CHEBI:3002 (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione D00689 DSSTox_GSID_48730 HMS2235O23 9-chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate KW-053 Aldecin NCGC00179392-01 Beclate Prestwick3_000855 Beclometasone 17,21-dipropionate QVAR 40 Beclomethasone dipropionate [USAN:USP] Sanasthmyl Beclovent Turbinal [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] propanoate BSPBio_000869 Clenil 32278-EP2281815A1 32278-EP2305640A2 EINECS 226-886-0 9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate HY-13571A AC1L2IWA MFCD00135613 AN-14214 Pregna-1,4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-, 17,21-dipropionate Beclocort Nasel Propaderm Forte Beclometasone dipropionate for peak identification, European Pharmacopoeia (EP) Reference Standard Rhino Clenil Beclomethasone dipropionate, anhydrous, European Pharmacopoeia (EP) Reference Standard SMR001233361 Beconase AQ Vanceril CAS-5534-09-8 CS-1503 534B098 HMS1570L11 9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate Korbutone AKOS015951275 NC00610 B4464 Prestwick1_000855 Beclomet Nasal Qnasl (TN) s3078 Beclorhinol ST24046007 ZINC3938744 BRD-K97810537-001-03-7 Ventolair (11beta,16beta)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate DB00394 [ Show all ]
Inchi Key	KUVIULQEHSCUHY-XYWKZLDCSA-N
Inchi ID	InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
PubChem CID	21700
ChEMBL	CHEMBL1200500
IUPHAR	5894
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.1 nM	PMID22575658	IUPHAR

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218