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GPCR

NameFree fatty acid receptor 2
SpeciesRattus norvegicus (Rat)
GeneFfar2
SynonymFFA2 receptor
FFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length330
Amino acid sequenceMTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE
UniProtQ76EI6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3309100
IUPHAR226
DrugBankN/A

Ligand

NameD09JXR
Molecular formulaC23H20Cl2N2O3S
IUPAC name3-benzyl-4-[cyclopropyl-[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]amino]-4-oxobutanoic acid
Molecular weight475.384
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.5
Synonyms3-{cyclopropyl[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]carbamoyl}-4-phenylbutanoic acid
GTPL6488
3-benzyl-4-(cyclopropyl-(4-(2,5-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid
compound 1 [PMID: 23589301]
SCHEMBL1914875
Inchi KeyLCRQPJWEPVZEBE-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H20Cl2N2O3S/c24-16-6-9-19(25)18(12-16)20-13-31-23(26-20)27(17-7-8-17)22(30)15(11-21(28)29)10-14-4-2-1-3-5-14/h1-6,9,12-13,15,17H,7-8,10-11H2,(H,28,29)
PubChem CID67209274
ChEMBLN/A
IUPHAR6488
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5079.4328 nMPMID23589301IUPHAR

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