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GLASS

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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	UDP-N-acetylglucosamine
Molecular formula	C17H27N3O17P2
IUPAC name	[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight	607.355
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.6
Synonyms	(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) DB03397 UDP N-acetyl-glucosamine UDP-N-acetyl-alpha-D-glucosamine Uridine 5'-diphospho-N-acetylglucosamine Uridine diphospho-N-acetyl-D-glucosamine URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE 91183-98-1 LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-acetyl-delta-glucosamine UDP-N-acetyl-glucosamine Uridine diphosphate N-acetyl-delta-glucosamine Uridine diphosphoacetylglucosamine [[3-acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinate CHEBI:16264 UD1 UDP-alpha-delta-N-acetylglucosamine UPPAG Uridine diphospho-2-acetamido-2-deoxy-D-glucose Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-delta-glucopyranosyl ester GTPL1779 UDP-a-D-N-acetylglucosamine UDP-N-acetyl-D-glucosamine uridine 5'-[3-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl) dihydrogen diphosphate] Uridine diphospho-N-acetyl-delta-glucosamine ZINC8551100 AC1L9IDL N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide UDP-acetylglucosamine uridine diphosphate N-acetylglucosamine Uridine pyrophosphate 2-acetamido-2-deoxy-a-D-glucopyranosyl ester [[3-acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinic acid D0KC2Z UD2 UDP-GlcNAc Uridine 5'-Diphospho-N-Acetlyglucosamine Uridine diphospho-2-acetamido-2-deoxy-delta-glucose uridine-diphosphate-n-acetylgalactosamine 528-04-1 J-700272 UDP-acetyl-D-glucosamine UDP-N-acetyl-delta-glucosamine Uridine diphosphate N-acetyl-D-glucosamine Uridine diphospho-N-acetylglucosamine [(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid C00043 SCHEMBL1521296 UDP-alpha-D-N-acetylglucosamine Udpx Uridine diphosphate-N-acetylglucosamine Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-D-glucopyranosyl ester [ Show all ]
Inchi Key	LFTYTUAZOPRMMI-CFRASDGPSA-N
Inchi ID	InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1
PubChem CID	445675
ChEMBL	N/A
IUPHAR	1779
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1000.0 nM	PMID19339661	IUPHAR

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