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GPCR

NameLysophosphatidic acid receptor 1
SpeciesMus musculus (Mouse)
GeneLpar1
SynonymVZG-1 {ECO:0000303|PubMed:8922387, ECO:0000303|PubMed:9600933}
Rec1.3 {ECO:0000303|PubMed:9013780}
Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9600933}
lysophosphatidic acid receptor Edg-2
Lpar1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProtP61793
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621025
IUPHAR272
DrugBankN/A

Ligand

NameKi16425
Molecular formulaC23H23ClN2O5S
IUPAC name3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylsulfanyl]propanoic acid
Molecular weight474.956
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP4.5
Synonyms3-(4-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-benzylsulfanyl)-propionic acid
4CA-0694
AOB33750
CHEMBL361501
HMS3654H15
[ Show all ]
Inchi KeyLLIFMNUXGDHTRO-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)
PubChem CID10367662
ChEMBLCHEMBL361501
IUPHAR2907
BindingDB50170859
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50130.0 - 250.0 nMPMID14500756IUPHAR

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