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GPCR

NamefMet-Leu-Phe receptor
SpeciesMus musculus (Mouse)
GeneFpr1
SynonymN-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
formyl peptide receptor 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM
UniProtP33766
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1770037
IUPHAR222
DrugBankN/A

Ligand

NamePyrazolone, 1
Molecular formulaC20H21ClN4O2
IUPAC name1-(4-chlorophenyl)-3-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea
Molecular weight384.864
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.1
Synonyms903895-98-7
UNII-T77D5438IM
CHEMBL379761
T77D5438IM
compound 43 [PMID:16697190]
[ Show all ]
Inchi KeyPAEBEUZTAPIOIO-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
PubChem CID24776341
ChEMBLCHEMBL379761
IUPHAR5831
BindingDB21692
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501.99526 nMPMID23160941IUPHAR

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