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GPCR

NameProto-oncogene Mas
SpeciesMus musculus (Mouse)
GeneMas1
Synonymangiotensin 1-7 receptor
MAS
MAS1
MAS1 proto-oncogene
MAS1 proto-oncogene, G protein-coupled receptor
DiseaseN/A for non-human GPCRs
Length324
Amino acid sequenceMDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
UniProtP30554
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR150
DrugBankN/A

Ligand

NameCHEBI:58922
Molecular formulaC41H62N12O11
IUPAC name(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-azaniumyl-3-carboxylatopropanoyl]amino]-5-(diaminomethylideneazaniumyl)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylate
Molecular weight899.02
Hydrogen bond acceptor12
Hydrogen bond donor11
XlogP-1.7
SynonymsIle(5)-angiotensin II (1-7) dizwitterion
Inchi KeyPVHLMTREZMEJCG-GDTLVBQBSA-N
Inchi IDInChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1
PubChem CID46878481
ChEMBLN/A
IUPHAR582
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC506.9 nMPMID12829792IUPHAR
Ki49.2 nMPMID21670420IUPHAR

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