Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA FASPR

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameProto-oncogene Mas
SpeciesHomo sapiens (Human)
GeneMAS1
SynonymMAS1
MAS1 proto-oncogene, G protein-coupled receptor
angiotensin 1-7 receptor
MAS1 proto-oncogene
MAS
DiseaseDiabetic foot ulcer
Sarcoma
Length325
Amino acid sequenceMDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV
UniProtP04201
Protein Data BankN/A
GPCR-HGmod modelP04201
3D structure modelThis predicted structure model is from GPCR-EXP P04201.
BioLiPN/A
Therapeutic Target DatabaseT91894
ChEMBLN/A
IUPHAR150
DrugBankN/A

Ligand

NameAR 244555
Molecular formulaC23H23ClF2N2O
IUPAC name(1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone
Molecular weight416.897
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.2
SynonymsAR244555
AR-244555
D0Z2FF
GTPL7042
SCHEMBL5578980
[ Show all ]
Inchi KeyQKPSTNGNDWHYCH-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H23ClF2N2O/c1-2-3-11-27-12-9-23(10-13-27)15-28(20-8-7-16(24)14-17(20)23)22(29)21-18(25)5-4-6-19(21)26/h2,4-8,14H,1,3,9-13,15H2
PubChem CID59004159
ChEMBLN/A
IUPHAR7042
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50186.0 nMPMID22003054IUPHAR

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218