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GPCR

NameP2Y purinoceptor 14
SpeciesHomo sapiens (Human)
GeneP2RY14
SynonymG-protein coupled receptor 105
GPR105
G protein-coupled receptor 105
P2Y purinoceptor 14
P2Y14
[ Show all ]
DiseaseN/A
Length338
Amino acid sequenceMINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProtQ15391
Protein Data BankN/A
GPCR-HGmod modelQ15391
3D structure modelThis predicted structure model is from GPCR-EXP Q15391.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4518
IUPHAR330
DrugBankN/A

Ligand

NameMRS2905
Molecular formulaC11H18N2O10P2S
IUPAC name2-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]ethylphosphonic acid
Molecular weight432.277
Hydrogen bond acceptor11
Hydrogen bond donor6
XlogP-4.4
SynonymsD09EGQ
GTPL5908
Inchi KeyRCFKBLDZKDFBNO-DOWZNPNQSA-N
Inchi IDInChI=1S/C11H18N2O10P2S/c14-7-1-2-13(11(26)12-7)10-9(16)8(15)6(23-10)5-22-25(20,21)4-3-24(17,18)19/h1-2,6,8-10,15-16H,3-5H2,(H,20,21)(H,12,14,26)(H2,17,18,19)/t6-,8+,9+,10-/m1/s1
PubChem CID91827348
ChEMBLN/A
IUPHAR5908
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
EC500.92 nMPMID21484092IUPHAR

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