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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL455016
Molecular formulaC14H25N5
IUPAC name4-tert-butyl-N-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight263.389
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.5
SynonymsN/A
Inchi KeyDAZPCCGCHIXHEO-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H25N5/c1-14(2,3)11-10-12(17-13(15-4)16-11)19-8-6-18(5)7-9-19/h10H,6-9H2,1-5H3,(H,15,16,17)
PubChem CID25130580
ChEMBLCHEMBL455016
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC505128.61 nMPMID18811133ChEMBL
Efficacy46.0 %PMID18811133ChEMBL

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