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GPCR

NameSphingosine 1-phosphate receptor 4
SpeciesMus musculus (Mouse)
GeneS1pr4
SynonymS1P4 receptor
S1P4
S1P receptor Edg-6
S1P receptor 4
Lysophospholipid receptor C1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST
UniProtQ9Z0L1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR278
DrugBankN/A

Ligand

NameAUY954
Molecular formulaC25H20F3NO2S
IUPAC name3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid
Molecular weight455.495
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.7
SynonymsAUY 954
D03BRM
GTPL2925
SCHEMBL2237377
AUY-954
[ Show all ]
Inchi KeySKYYWSWIUKISCX-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H20F3NO2S/c26-25(27,28)21-13-18(7-8-20(21)17-4-2-1-3-5-17)23-14-19-12-16(6-9-22(19)32-23)15-29-11-10-24(30)31/h1-9,12-14,29H,10-11,15H2,(H,30,31)
PubChem CID11259583
ChEMBLN/A
IUPHAR2925
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501000.0 - 10000.0 nMPMID17114004IUPHAR

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