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GPCR

NameLysophosphatidic acid receptor 3
SpeciesMus musculus (Mouse)
GeneLpar3
SynonymEdg7
endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7
LPA-3
Lysophosphatidic acid receptor Edg-7
LPA receptor 3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSETGSQYLEDSISQGPVCNKNGS
UniProtQ9EQ31
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR274
DrugBankN/A

Ligand

Namelysophosphatidic acid
Molecular formulaC21H41O7P
IUPAC name(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
Molecular weight436.526
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP5.2
Synonyms(2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoate
(2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoic acid
(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
1-(9Z-octadecenoyl)-phosphatidic acid
1-monooleoylglycerol 3-phosphate
[ Show all ]
Inchi KeyWRGQSWVCFNIUNZ-KTKRTIGZSA-N
Inchi IDInChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
PubChem CID5497152
ChEMBLN/A
IUPHAR2906
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50253.0 nMPMID18781939IUPHAR

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