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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cysteinyl leukotriene receptor 2
Species	Homo sapiens (Human)
Gene	CYSLTR2
Synonym	CysLTR2 CysLT2 receptor LTC4 HPN321 hGPCR21 HG57 G-protein coupled receptor HG57 CYSLT2R G-protein coupled receptor GPCR21 [ Show all ]
Disease	Unspecified Asthma
Length	346
Amino acid sequence	MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProt	Q9NS75
Protein Data Bank	N/A
GPCR-HGmod model	Q9NS75
3D structure model	This predicted structure model is from GPCR-EXP Q9NS75.
BioLiP	N/A
Therapeutic Target Database	T74238
ChEMBL	CHEMBL4330
IUPHAR	270
DrugBank	BE0000099

Ligand

Name	leukotriene D4
Molecular formula	C25H40N2O6S
IUPAC name	(5S,6R,7E,9E,11Z,14Z)-6-[2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Molecular weight	496.663
Hydrogen bond acceptor	8
Hydrogen bond donor	5
XlogP	1.4
Synonyms	27833-EP2270113A1 27833-EP2305254A1 27833-EP2371811A2 73836-78-9 GTPL3353 NCGC00161277-01 SMP2_000046 27833-EP2289882A1 27833-EP2308857A1 27833-EP2374788A1 CHEMBL1521056 [3H]LTD4 (5S,6R,7E,9E,11Z,14Z)-6-[2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid 27833-EP2295406A1 27833-EP2314587A1 DTXSID6040533 LTD (sub 4) 27833-EP2270114A1 27833-EP2305627A1 27833-EP2372017A1 AC1O5JI4 GTPL3412 S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]cysteinylglycine YEESKJGWJFYOOK-LDDGIIIKSA-N 27833-EP2289886A1 27833-EP2308865A1 27833-EP2374895A1 D03YBH LS-72362 27833-EP2270101A1 27833-EP2298767A1 27833-EP2371810A1 5(S)-Hydroxy-6(R)-S-cysteinylglycinyl-7-trans-9-trans-11-cis-14-cis-eicosatetraenoic Acid Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R,S-(E,E,Z,Z)))- LTD4 27833-EP2272849A1 27833-EP2308509A1 27833-EP2374787A1 BML1-E08 Leukotriene D(sub 4) SCHEMBL4295683 [3H]-LTD4 (5S,6R,7E,9E,11Z,14Z)-6-({2-amino-2-[(carboxymethyl)carbamoyl]ethyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid 27833-EP2292592A1 27833-EP2309584A1 D0B2WI LTD [ Show all ]
Inchi Key	YEESKJGWJFYOOK-LDDGIIIKSA-N
Inchi ID	InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20?,21-,22+/m0/s1
PubChem CID	6435286
ChEMBL	N/A
IUPHAR	3412, 3353
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.5 - 9.3 nM	PMID10913337, PMID11093801, PMID21753081	IUPHAR
EC50	35.0 nM	PMID21078884	IUPHAR
EC50	36.0 nM	PMID21753081	IUPHAR
EC50	104.0 - 144.0 nM	PMID10851239, PMID21078884	IUPHAR
IC50	7.0 nM	PMID11093801	IUPHAR
IC50	59.0 nM	PMID10913337	IUPHAR
Kd	0.398 - 50.1 nM	PMID10851239	IUPHAR
Ki	7.94328 - 50.1187 nM	PMID9547367	IUPHAR

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