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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Rattus norvegicus (Rat)
Gene	Ptgdr
Synonym	DP1 receptor PGD receptor PGD2 receptor DP1 prostaglandin D2 receptor (DP) Prostanoid DP receptor prostanoid DP receptor-like PTGDR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MNESYRCQAATWVERGSSATMGGVAFSAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNRSLKELLPASGNQLCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQRHITARRGVLVAPVAGAFSLAFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLVLATVVCNLGAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMCSLPLIYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKTFTRPLIYRNWCSHSWQTNMESTL
UniProt	Q9R261
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	338
DrugBank	N/A

Ligand

Name	BW 245C
Molecular formula	C19H32N2O5
IUPAC name	7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid
Molecular weight	368.474
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.9
Synonyms	5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin AKOS030549066 CTK2H7632 MLS002172471 (4S)-(3-[(3R,S)-3-Cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidine-heptanoic acid 72814-32-5 BW245C GTPL1878 SCHEMBL9488992 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R,S)-(+/-)-4-imidazolineheptanioc acid 4-Imidazolidineheptanoicacid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo- AC1Q5W5W L000151 7-(3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl)heptanoic acid D0R9CC NCGC00015170-03 75693-75-3 C-28736 HMS2235D12 SMR000058929 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin AC1Q77DO CHEMBL575504 MLS000028690 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid BW-245C EINECS 278-291-0 REGID_for_CID_119304 AC1L3OKB CHEBI:131502 HMS3369D02 ZIDQIOZJEJFMOH-UHFFFAOYSA-N 4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo- [ Show all ]
Inchi Key	ZIDQIOZJEJFMOH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H32N2O5/c22-16(14-8-4-3-5-9-14)12-13-21-15(18(25)20-19(21)26)10-6-1-2-7-11-17(23)24/h14-16,22H,1-13H2,(H,23,24)(H,20,25,26)
PubChem CID	119304
ChEMBL	CHEMBL575504
IUPHAR	1878
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.8489 nM	PMID10448933	IUPHAR

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