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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameMELPERONE
Molecular formulaC16H22FNO
IUPAC name1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
Molecular weight263.356
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.3
Synonyms1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone
1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
1622-79-3 (hydrochloride)
3575-80-2
4'-Fluor-4-(4-methylpiperidino)-butyrophenone
[ Show all ]
Inchi KeyDKMFBWQBDIGMHM-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3
PubChem CID15387
ChEMBLN/A
IUPHARN/A
BindingDB81771
DrugBankDB09224

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki578.0 nMPMID7908055BindingDB

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